Tumor Immunology

In order for tumors to become malignant, cancer cells must: (1) dysregulate cell cycling programs, (2) disrupt apoptotic pathways, and (3) establish new vascular networks to allow for increased tumor burden. We now recognize that a fourth step is required - all solid tumors must escape immune detection. The Sebzda lab is actively studying how cancers interact with the immune system to achieve this tumor-specific immune suppression. Using gene targeted mouse models that impact specific white blood cell lineages, we are identifying biological functions that are co-opted by tumor cells to avoid immune clearance. In turn, we are leveraging these biological events to create new pre-clinical therapies to treat solid tumors.